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Unusual Hybrid Materials Prepared by the Oxidation of a Ketone

Lookup NU author(s): Dr Ross Harrington, Emeritus Professor Bill Clegg

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Abstract

Four new layered phases have been synthesized by the hydrothermal reactions of zinc and magnesium salts with fenbufen (gamma-oxo-(1,1'-biphenyl)-4-butanoic acid) as a result of the oxidation of fenbufen at the ketone forming biphenylcarboxylate. Reactions with zinc nitrate give different degrees of oxidation, yielding Zn(C16H13O3) (C13H9O2) (H2O) (1) and Zn-5(OH)(6)(C13H9O2)(4) (2), depending on the reaction temperature. Compound 2 has an unusual zinc hydroxide layer structure which contains hydroxide-centered Zn4OH(OH)(4) units where the central hydroxide has two long and two short bonds to the Zn atoms. The mechanism for the ketone oxidation has been investigated by a series of DFT calculations which indicate that a concerted, metal-mediated pathway is lower in energy than a two-step process. The importance of the metal cation in this oxidation reaction has been shown by demonstrating that oxidation of fenbufen also occurs during reactions with magnesium nitrate and zinc chloride. These reactions yielded fully oxidized Mg(C13H9O2)(2)(H2O)(2) (3) and half-oxidized Zn(C16H13O3)(C13H9O2)(H2O) (4), a polymorph of 1. Reactions with ammonium salts gave only recrystallized fenbufen, providing further evidence for the role of the metal cation in these oxidation reactions.


Publication metadata

Author(s): Holden DL, Goulding HV, Bacsa J, Berry NG, Greeves N, Stephenson RA, Harrington RW, Clegg W, Fogg AM

Publication type: Article

Publication status: Published

Journal: Crystal Growth & Design

Year: 2011

Volume: 11

Issue: 7

Pages: 3013-3019

Print publication date: 17/05/2011

ISSN (print): 1528-7483

ISSN (electronic): 1528-7505

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/cg200286t

DOI: 10.1021/cg200286t


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