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Age-associated decline in high-affinity nicotine binding in human brain frontal-cortex does not correlate with the changes in choline-acetyltransferase activity

Lookup NU author(s): Dr Jennifer Court, Dr Margaret Piggott, Emeritus Professor Elaine Perry, Emeritus Professor Robert Perry


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[H-3]nicotine binding and choline acetyltransferase activity were measured in human frontal cortex, Brodman area 9, from brains obtained at autopsy from 47 cases aged between 24 weeks gestation to 100 years. The pattern of change of [H-3]nicotine binding during development and aging was not reflected in the changes of CHAT activity. [H-3]nicotine binding was reduced with age from birth to 100 years and this was not due to a change in affinity of the receptor for nicotine. CHAT activity initially rose from the perinatal period to a peak in the first decade and was then stable throughout the remaining years of life.

Publication metadata

Author(s): Court JA, Piggott MA, Perry EK, Barlow RB, Perry RH

Publication type: Article

Publication status: Published

Journal: Neuroscience Research Communications

Year: 1992

Volume: 10

Issue: 3

Pages: 125-133

Print publication date: 01/05/1992

ISSN (print): 0893-6609

ISSN (electronic): 1520-6769

Publisher: John Wiley & Sons Ltd