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Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium

Lookup NU author(s): Professor Peter Thomson


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We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p (trend) < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p (trend) = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97).

Publication metadata

Author(s): Chuang SC, Jenab M, Heck JE, Bosetti C, Talamini R, Matsuo K, Castellsague X, Franceschi S, Herrero R, Winn DM, La Vecchia C, Morgenstern H, Zhang ZF, Levi F, Dal Maso L, Kelsey K, McClean MD, Vaughan T, Lazarus P, Muscat J, Ramroth H, Chen C, Schwartz SM, Eluf-Neto J, Hayes RB, Purdue M, Boccia S, Cadoni G, Zaridze D, Koifman S, Curado MP, Ahrens W, Benhamou S, Matos E, Lagiou P, Szeszenia-Dabrowska N, Olshan AF, Fernandez L, Menezes A, Agudo A, Daudt AW, Merletti F, Macfarlane GJ, Kjaerheim K, Mates D, Holcatova I, Schantz S, Yu GP, Simonato L, Brenner H, Mueller H, Conway DI, Thomson P, Fabianova E, Znaor A, Rudnai P, Healy CM, Ferro G, Brennan P, Boffetta P, Hashibe M

Publication type: Article

Publication status: Published

Journal: Cancer Causes & Control

Year: 2012

Volume: 23

Issue: 1

Pages: 69-88

Print publication date: 01/01/2012

ISSN (print): 0957-5243

ISSN (electronic): 1573-7225

Publisher: Springer Netherlands


DOI: 10.1007/s10552-011-9857-x


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Funder referenceFunder name
AIRC (Italian Agency for Research on Cancer)
IMIM (Barcelona)
International Union Against Cancer (UICC)
Ministry of Science, Research and Arts Baden-Wurttemberg
National Cancer Institute, National Institutes of Health, USA
National Institutes of Health (NCI) US
World Cancer Research Fund
Compagnia di San Paolo/FIRMS
Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina
International Agency for Research on Cancer
Italian Association for Cancer Research
Italian Association for Research on Cancer (AIRC)
Italian League against Cancer
Italian Ministry of Research
Region Piemonte
UCLA Jonsson Comprehensive Cancer Center
Yamagiwa-Yoshida Memorial International Cancer Study Grant
01/01768-2Fundacao de Amparo a Pesquisa no. Estado de Sao Paulo (FAPESP)
01GB9702/3German Ministry of Education and Research
17015052Ministry of Education, Science, Sports, Culture and Technology of Japan
AKT 617Swiss Cancer Research
BAE 01/5013Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government
88D28Gustave-Roussy Institute
CPDA057222Padova University
FIS 97/0024Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government
FIS 97/0662Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government
FOR381.88Fribourg League against Cancer
H20-002Ministry of Health, Labor and Welfare of Japan
IC15-CT98-0332European Commission
K07CA104231National Institutes of Health (NIH) US
KFS-700Swiss Research against Cancer/Oncosuisse
IC18-CT97-0222European Commission
KFS1069-09-2000Swiss League against Cancer
P01CA068384National Institutes of Health (NIH) US
P30ES010126National Institute of Environmental Health Sciences
P50CA90388National Institutes of Health (NIH) US
QLK1-2001-00182European Commission
R01CA048996National Institutes of Health (NIH) US
R01CA078609National Institutes of Health (NIH) US
R01CA100679National Institutes of Health (NIH) US
R01DE012609National Institutes of Health (NIH) US
R03CA113157US National Institutes of Health (NIH), National Cancer Institute (NCI)
R03CA77954National Institutes of Health (NIH) US
R03DE016611National Institute for Dental and Craniofacial Research (NIDCR)
OCS-1633Swiss Research against Cancer/Oncosuisse
U01CA96134National Institutes of Health (NIH) US
R01CA61188National Institutes of Health (NIH) US
R01DA11386National Institutes of Health (NIH) US
R01DE13158National Institutes of Health (NIH) US
R21ES011667National Institutes of Health (NIH) US
T32CA09142National Institutes of Health (NIH) US