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Lookup NU author(s): Professor Michael Taggart,
Dr Wing Tong
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We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour. (C) 2011 Elsevier Ltd. All rights reserved.
Author(s): Aslanidi O, Atia J, Benson AP, van den Berg HA, Blanks AM, Choi C, Gilbert SH, Goryanin I, Hayes-Gill BR, Holden AV, Li P, Norman JE, Shmygol A, Simpson NAB, Taggart MJ, Tong WC, Zhang H
Publication type: Review
Publication status: Published
Journal: Progress in Biophysics & Molecular Biology
Print publication date: 13/07/2011
ISSN (print): 0079-6107
ISSN (electronic): 1873-1732
Publisher: PERGAMON-ELSEVIER SCIENCE LTD