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Towards a computational reconstruction of the electrodynamics of premature and full term human labour

Lookup NU author(s): Professor Michael TaggartORCiD, Dr Wing Tong

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Abstract

We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour. (C) 2011 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Aslanidi O, Atia J, Benson AP, van den Berg HA, Blanks AM, Choi C, Gilbert SH, Goryanin I, Hayes-Gill BR, Holden AV, Li P, Norman JE, Shmygol A, Simpson NAB, Taggart MJ, Tong WC, Zhang H

Publication type: Review

Publication status: Published

Journal: Progress in Biophysics & Molecular Biology

Year: 2011

Volume: 107

Issue: 1

Pages: 183-192

Print publication date: 13/07/2011

ISSN (print): 0079-6107

ISSN (electronic): 1873-1732

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

URL: http://dx.doi.org/10.1016/j.pbiomolbio.2011.07.004

DOI: 10.1016/j.pbiomolbio.2011.07.004

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