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Cysteine 38 Holds the Key to NF-kappa B Activation

Lookup NU author(s): Professor Neil PerkinsORCiD


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The importance of parallel signaling pathways controlling NF-kappa B subunit posttranslational modifications is demonstrated by Sen et al. (2012), who reveal that RelA (p65) sulfhydration, at its highly conserved cysteine 38 residue, regulates association with the coactivator RPS3, DNA binding, and antiapoptotic gene expression.

Publication metadata

Author(s): Perkins ND

Publication type: Editorial

Publication status: Published

Journal: Molecular Cell

Year: 2012

Volume: 45

Issue: 1

Pages: 1-3

Print publication date: 12/01/2012

ISSN (print): 1097-2765

ISSN (electronic): 1097-4164

Publisher: Cell Press


DOI: 10.1016/j.molcel.2011.12.023