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Lookup NU author(s): Professor John Dark
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Over the course of the last century, organ transplantation has overcome major technical limitations to become the success it is today. The breakthroughs include developing techniques for vascular anastomoses, managing the immune response (initially by avoiding it with the use of identical twins and subsequently controlling it with chemical immunosuppressants), and devising preservation solutions that enable prolonged periods of ex vivo storage while preserving function. One challenge that has remained from the outset is to overcome the shortage of suitable donor organs. The results of organ transplantation continue to improve, both as a consequence of the above innovations and the improvements in peri- and postoperative management. This review describes some of the achievements and challenges of organ transplantation.
Author(s): Watson CJE, Dark JH
Publication type: Review
Publication status: Published
Journal: British Journal of Anaesthesia
Year: 2012
Volume: 108
Issue: s1
Pages: i29-i42
Print publication date: 01/01/2012
ISSN (print): 0007-0912
ISSN (electronic): 1471-6771
Publisher: OXFORD UNIV PRESS
URL: http://dx.doi.org/10.1093/bja/aer384
DOI: 10.1093/bja/aer384
