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Contribution of sociodemographic characteristics, occupation, diet and lifestyle to DDT and DDE concentrations in serum and adipose tissue from a Bolivian cohort

Lookup NU author(s): Dr Elaine Mutch


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The organochlorine pesticide p,p'-Dichlorodiphenyltrichloroethane (DDT) was widely used in the early 1960s-70s for vector control in tropical and subtropical areas of South America. Due to its persistence, DDT has a high potential to bioaccumulate in the food chain and living organisms and is a major public health concern, especially in South America. The main purpose of the present study was to investigate predictors of serum and adipose tissue concentrations of p,p'-DDT and its main metabolite, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), in an adult cohort (n = 112) from Santa Cruz de la Sierra, Bolivia, using multiple linear regression models. These models explained 29.3-47.8% of the variability in adipose tissue concentrations of p,p'-DDT and p,p'-DDE, respectively, and 32.9-47.0% of that in serum. Main exposure predictors included age, occupational class, residence, diet, smoking habit, and accumulated breastfeeding time. This is one of the few studies to explore predictors of human exposure to these chemicals using a multivariate approach in a South American population. Results show that predictors of human exposure to p,p'-DDT and p,p'-DDE in Santa Cruz de la Sierra may diverge from those found in other populations of the world, due to particular sociodemographic and lifestyle characteristics of this region. (C) 2011 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Arrebola JP, Mutch E, Rivero M, Choque A, Silvestre S, Olea N, Ocana-Riola R, Mercado LA

Publication type: Article

Publication status: Published

Journal: Environment International

Year: 2012

Volume: 38

Issue: 1

Pages: 54-61

Print publication date: 15/09/2011

ISSN (print): 0160-4120

ISSN (electronic): 1873-6750

Publisher: Pergamon


DOI: 10.1016/j.envint.2011.08.006


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