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Lookup NU author(s): Manuel Banzhaf,
Professor Waldemar Vollmer
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How bacteria grow and divide while retaining a defined shape is a fundamental question in microbiology, but technological advances are now driving a new understanding of how the shape-maintaining bacterial peptidoglycan sacculus grows. In this Review, we highlight the relationship between peptidoglycan synthesis complexes and cytoskeletal elements, as well as recent evidence that peptidoglycan growth is regulated from outside the sacculus in Gram-negative bacteria. We also discuss how growth of the sacculus is sensitive to mechanical force and nutritional status, and describe the roles of peptidoglycan hydrolases in generating cell shape and of D-amino acids in sacculus remodelling.
Author(s): Typas A, Banzhaf M, Gross CA, Vollmer W
Publication type: Review
Publication status: Published
Journal: Nature Reviews Microbiology
Print publication date: 01/02/2012
ISSN (print): 1740-1526
Publisher: NATURE PUBLISHING GROUP