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The Impact of Common Gene Variants on the Response of Biomarkers of Cardiovascular Disease (CVD) Risk to Increased Fish Oil Fatty Acids Intakes

Lookup NU author(s): Professor Georg Lietz, Professor John Mathers


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The cardioprotectivc actions of the fish oil (FO)-derived long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated, and dose-response relationships have been defined. However, there is a substantial and well-recognized within-population heterogeneity in response to FO, the etiology of which is poorly understood. Genetic variation may influence responsiveness. Here we review the available literature relating to gene variants shown to influence tissue LC n-3 PUFA status and response to FO intervention. From this review we conclude that the available evidence is relatively limited. A number of individual genotype x LC-n3 PUFA x phenotype associations have been described, but few have been investigated in subsequent cohorts or confirmed in independent studies. in the context of a more stratified approach to the provision of dietary advice, there is a need for further research to refine current dietary EPA and DHA recommendations.

Publication metadata

Author(s): Madden J, Williams CM, Calder PC, Lietz G, Miles EA, Cordell H, Mathers JC, Minihane AM

Editor(s): Cousins, R.J., Bier, D.M., Bowman, B.A.

Publication type: Book Chapter

Publication status: Published

Book Title: Annual Review of Nutrition

Year: 2011

Volume: 31

Pages: 203-234

Print publication date: 01/01/2011

Publisher: Annual Reviews

Place Published: Palo Alto, California, USA


DOI: 10.1146/annurev-nutr-010411-095239

Notes: ISSN: 0199-9885

Library holdings: Search Newcastle University Library for this item

ISBN: 9780824328313