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Gross energy metabolism in mice under late onset, short term caloric restriction

Lookup NU author(s): Dr Kerry Cameron, Dr Andrew Golightly, Dr Satomi Miwa, Professor Richard Boys, Professor Thomas von Zglinicki


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Late onset, short-term moderate caloric restriction (CR) may have beneficial health effects. A 26% CR regime induced at 14 months of age for 70 days in male C57BI/6 (ICRFa) mice resulted in a reduction in body mass of 17%. A decrease in daily energy expenditure was associated with decreased body mass in CR mice. There was no difference in total levels of physical activity between the CR and ad libitum (AL) groups: however, activity patterns were different. We developed a Bayesian model to dissect the impact of food anticipation activity (FAA) and feeding on physical activity. FAA was stronger in CR mice and remaining basal activity was higher in AL mice, but CR mice displayed larger diurnal variations as well as a phase shift in their diurnal activity. CR mice displayed lower body temperature, especially late during the dark phase. This was due to lower basal (activity-independent) temperature at all times of the day, coupled to a phase shift in the diurnal rhythm. The correlation between body temperature and physical activity was independent of feeding regimen and light/dark cycles. Reduction of body mass and basal temperature were major compensatory mechanisms to reduced food availability during late-onset, short-term CR. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Cameron KM, Golightly A, Miwa S, Speakman J, Boys R, von Zglinicki T

Publication type: Article

Publication status: Published

Journal: Mechanisms of Ageing and Development

Year: 2011

Volume: 132

Issue: 4

Pages: 202-209

Print publication date: 09/04/2011

ISSN (print): 0047-6374

ISSN (electronic): 1872-6216

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.mad.2011.04.004

PubMed id: 21507329


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