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Nucleoid occlusion and bacterial cell division

Lookup NU author(s): Dr Ling Juan Wu, Professor Jeff ErringtonORCiD


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The bacterial cell cycle requires the tight regulation and precise coordination of several sophisticated cellular processes. Prominent among them is the formation of the dividing wall or septum, which has to take place at the right time and place to ensure equality of the progeny and integrity of the genome. Nucleoid occlusion is a defence mechanism that prevents the chromosome from being bisected and broken by the division septum. It does so by preventing Z ring formation near the nucleoid, which also helps to determine the location of septation.

Publication metadata

Author(s): Wu LJ, Errington J

Publication type: Review

Publication status: Published

Journal: Nature Reviews Microbiology

Year: 2012

Volume: 10

Issue: 1

Pages: 8-12

Print publication date: 01/01/2012

ISSN (print): 1740-1526

ISSN (electronic):



DOI: 10.1038/nrmicro2671