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Ovulation induction with clomifene: a primary care perspective

Lookup NU author(s): Dr Scott Wilkes, Professor Alison Murdoch


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Infertility affects one in seven couples during their lifetime. Approximately one-quarter of these will have an ovulatory disorder contributing to their inability to conceive. Ovulatory disorders represent the simplest form of infertility to treat, and where this is not a result of ovarian failure or poor ovarian reserve most women require ovulation induction with clomifene citrate (CC). This review aims to examine the role of CC in a general practice setting. CC is a simple, relatively safe, easily administered and well-tolerated efficacious drug. There is, however, a 10% risk of multiple births associated with its use. CC has been used in general practice for many years and continues to be used. Currently, guidelines do not describe its use in the general practice setting and the evidence for monitoring its use with mid-luteal progesterone estimation or ultrasound scanning is conflicting.

Publication metadata

Author(s): Wilkes S, Murdoch A

Publication type: Review

Publication status: Published

Journal: Journal of Family Planning and Reproductive Health Care

Year: 2012

Volume: 38

Issue: 1

Pages: 48-52

Print publication date: 07/08/2011

ISSN (print): 1471-1893

ISSN (electronic): 2045-2098



DOI: 10.1136/jfprhc-2011-0103