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Gene-gene interactions in breast cancer susceptibility

Lookup NU author(s): Dr Fiona Douglas


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There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 combined, P = 5.9 x 10(-4); ATM and BRCA1, P = 0.01; ATM and BRCA2, P = 0.02; CHEK2 and BRCA1/BRCA2 combined, P = 2.1 x 10(-4); CHEK2 and BRCA1, P = 0.01; CHEK2 and BRCA2, P = 0.01). The interactions are such that the resultant risk of breast cancer is lower than the multiplicative product of the constituent risks, and plausibly reflect the functional relationships of the encoded proteins in DNA repair. These findings have important implications for models of disease predisposition and clinical translation.

Publication metadata

Author(s): Turnbull C, Seal S, Renwick A, Warren-Perry M, Hughes D, Elliott A, Pernet D, Peock S, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Ahmed M, Eccles D, Evans DG, Donnelly P, Easton DF, Stratton MR, Rahman N, Breast Canc Susceptibility, EMBRACE

Publication type: Article

Publication status: Published

Journal: Human Molecular Genetics

Year: 2012

Volume: 21

Issue: 4

Pages: 958-962

Print publication date: 09/11/2011

ISSN (print): 0964-6906

ISSN (electronic): 1460-2083

Publisher: Oxford University Press


DOI: 10.1093/hmg/ddr525


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Funder referenceFunder name
Institute of Cancer Research (UK)
Medical Research Council
National Health Service
US Military Acquisition (ACQ) Activity
Wolfson-Royal Society
068545/Z/02Wellcome Trust
C1287/A10118Cancer Research UK
C1287/A8874Cancer Research UK
C8620/A8372Cancer Research UK
C8620/A8857Cancer Research UK
G0000934Medical Research Council
W81XWH-05-1-0204Era of Hope Award