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The diverse and complex roles of NF-kappa B subunits in cancer.

Lookup NU author(s): Professor Neil PerkinsORCiD


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It is only recently that the full importance of nuclear factor-kappa B (NF-kappa B) signalling to cancer development has been understood. Although much attention has focused on the upstream pathways leading to NF-kappa B activation, it is now becoming clear that the inhibitor of NF-kappa B kinases (IKKs), which regulate NF-kappa B activation, have many independent functions in tissue homeostasis and normal immune function that could compromise the clinical utility of IKK inhibitors. Therefore, if the NF-kappa B pathway is to be properly exploited as a target for both anticancer and anti-inflammatory drugs, it is appropriate to reconsider the complex roles of the individual NF-kappa B subunits.

Publication metadata

Author(s): Perkins ND

Publication type: Review

Publication status: Published

Journal: Nature Reviews. Cancer

Year: 2012

Volume: 12

Issue: 2

Pages: 121-132

Print publication date: 19/01/2012

ISSN (print): 1474-175X

ISSN (electronic): 1474-1768



DOI: 10.1038/nrc3204