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Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study

Lookup NU author(s): Dr Timo Erkinjuntti, Professor John O'Brien


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Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to non-converters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment. Copyright (C) 2012 S. Karger AG, Basel

Publication metadata

Author(s): Frederiksen KS, Garde E, Skimminge A, Barkhof F, Scheltens P, van Straaten ECW, Fazekas F, Baezner H, Verdelho A, Ferro JM, Erkinjuntti T, Jokinen H, Wahlund LO, O'Brien JT, Basile AM, Pantoni L, Inzitari D, Waldemar G, LADIS Study Grp

Publication type: Article

Publication status: Published

Journal: Dementia and Geriatric Cognitive Disorders

Year: 2012

Volume: 32

Issue: 4

Pages: 279-286

Print publication date: 01/02/2012

ISSN (print): 1420-8008

ISSN (electronic): 1421-9824

Publisher: S. Karger AG


DOI: 10.1159/000334949


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Funder referenceFunder name
Danish Velux Foundation
Faculty of Health Sciences, University of Copenhagen
Helsinki University Central Hospital
Vanderbilt University Medical Center
Clinical Research Institute
Danish Health Foundation
Danish Ministry of Health
Danish Strategic Research Council
Ella and Georg Ehrnrooth Foundation
Lundbeck Foundation
Spies Foundation
QLRT-2000-00446European Union