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Agressive fibromatosis involving the mandible: Case report and review of the literature

Lookup NU author(s): Professor Hermann Josef Vormoor


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BACKGROUND: Aggressive fibromatosis (AF) involving the mandible is rare, and surgery is often complicated by a high recurrence rate. CASE REPORT: A 4-year-old boy was referred because of a fast growing painless mass which involved the entire left angle of the mandible. Excisional biopsy revealed AF, and local excision of the tumor was performed. Six months after surgery a recurrence was detected. The tumor was determined to be unresectable and the boy was treated with low-dose chemotherapy including methotrexate and vinblastine for 1 year. With combined chemotherapy and surgical debulking, mutilating surgical resection will be delayed as long as possible or until completion of facial growth. CONCLUSION: According to the literature, surgery is the most common treatment of AF in the head and neck region. However, particularly in children, alternative modes of therapy must be considered because of the high recurrence rate and to avoid mutilating operations.

Publication metadata

Author(s): Seper L, Bürger H, Vormoor J, Joos U, Kleinheinz J

Publication type: Article

Publication status: Published

Journal: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology

Year: 2005

Volume: 99

Issue: 1

Pages: 30-38

Print publication date: 01/01/2005

ISSN (print): 1079-2104

ISSN (electronic): 1528-395X


DOI: 10.1016/j.tripleo.2004.03.026

Notes: 1079-2104 (Print) Case Reports Journal Article Review


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