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Serum matrix metalloproteinase-9 (MMP-9) as a biomarker for monitoring disease progression in Duchenne muscular dystrophy (DMD)

Lookup NU author(s): Dr Amina Chaouch, Dr Penelope Garrood, Professor Volker Straub, Professor Hanns Lochmuller

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Abstract

To identify serum biomarkers that allow monitoring of disease progression and treatment effects in Duchenne muscular dystrophy (DMD) patients, levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitors of metalloproteinase-1 (TIMP-1) and osteopontin (OPN) were determined in 63 DMD patients on corticosteroid therapy. These proteins were selected for their role in the pathogenesis of muscular dystrophy. Levels of MMP-9 and TIMP-1 were significantly higher in sera of DMD patients compared to healthy controls, whereas the OPN levels showed no significant difference. MMP-9 levels were also observed to be significantly higher in older, nonambulant patients, compared to ambulant patients. Longitudinal data from a smaller cohort of DMD patients followed up for over 4 years showed that MMP-9, but not TIMP-1 increased significantly with age. Hence, MMP-9 is a potential DMD biomarker for disease progression. Future studies have to confirm whether serum MMP-9 levels can be used to monitor therapeutic response. (C) 2011 Elsevier B.V. All rights reserved.


Publication metadata

Author(s): Nadarajah VD, van Putten M, Chaouch A, Garrood P, Straub V, Lochmuller H, Ginjaar HB, Aartsma-Rus AM, van Ommen GJB, den Dunnen JT, 't Hoen PAC

Publication type: Article

Publication status: Published

Journal: Neuromuscular Disorders

Year: 2011

Volume: 21

Issue: 8

Pages: 569-578

Print publication date: 02/07/2011

ISSN (print): 0960-8966

ISSN (electronic): 1873-2364

Publisher: Elsevier Ltd

URL: http://dx.doi.org/10.1016/j.nmd.2011.05.011

DOI: 10.1016/j.nmd.2011.05.011

PubMed id: 21724396


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