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Lookup NU author(s): Professor Lyle Armstrong
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Pluripotent embryonic stem cells can give rise to almost all somatic cell types but this characteristic requires precise control of their gene expression patterns. The necessity of keeping the entire genome "poised" to enter into any of a number of developmental possibilities requires a unique and highly plastic chromatin organisation based around specific patterns of histone modifications although this state of affairs is normally short lived during embryonic development. By deriving embryonic stem cells from the early embryo, we can preserve the highly specialised genome organisation and this has permitted several detailed investigations into the molecular basis of pluripotency.
Author(s): Armstrong L
Publication type: Article
Publication status: Published
Journal: Stem Cell Reviews and Reports
Print publication date: 01/03/2012
ISSN (print): 1550-8943
ISSN (electronic): 1558-6804
Publisher: Humana Press, Inc.
PubMed id: 21808982
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