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Biomimetic mineralization: Long-term observations in patients with dentin sensitivity

Lookup NU author(s): Professor Philip Preshaw


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Objective. Cervical tooth erosion is increasingly observed among adults and frequently associated with dentin sensitivity (DS). This study evaluated the effectiveness on DS of a biomimetic mineralization system (BIMIN) in comparison to the current standard treatment (Gluma (R) Desensitizer, Gluma). Methods. In this single-blind, 2-arm study, 40 patients with confirmed cervical DS were randomized to either the test group or the positive control group. A Visual-Analog-Scale (VAS) was used to assess DS following stimulation of the exposed dentin with a 2-s air blast. Assessments were made at baseline (pre-treatment), 2 days, 4, 8 and 12 weeks, and 12 months after treatment. Two-stage replicas were obtained from the treated teeth and gold sputtered at baseline, and 2 days, 3 and 12 months after treatment. Surface topography of the treated cervical lesions and occlusion of dentinal tubules were investigated using scanning electron microscopy (SEM). Results. Both treatments led to a statistically significant reduction (P < 0.0001) in DS that persisted over the entire 12-month observation period. Differences in DS between the treatments were not statistically significant. SEM photomicrographs demonstrated that a mineral layer concealed the dentinal tubules in the test group. In contrast, numerous dentinal tubules remained visible in cervical defects that were treated with Gluma. Significance. A biomimetic mineralization kit was successfully used to treat patients exhibiting DS. The effect was similar to using Gluma, and was likely the result of the deposition of an enamel-like layer on the exposed cervical dentin. (C) 2012 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Guentsch A, Seidler K, Nietzsche S, Hefti AF, Preshaw PM, Watts DC, Jandt KD, Sigusch BW

Publication type: Article

Publication status: Published

Journal: Dental Materials

Year: 2012

Volume: 28

Issue: 4

Pages: 457-464

Print publication date: 02/02/2012

ISSN (print): 0109-5641

ISSN (electronic): 1879-0097

Publisher: Elsevier Inc.


DOI: 10.1016/


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Funder referenceFunder name
Alexander von Humboldt Foundation, Bonn, Germany
HKG-DT-01/2008-BIMINHeraeus Kulzer GmbH, Hanau, Germany