Toggle Main Menu Toggle Search

Open Access padlockePrints

Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study

Lookup NU author(s): Dr Sean Colloby, Dr Michael FirbankORCiD, Professor Alan ThomasORCiD, Dr Akshya Vasudev, Dr Steve Parry, Professor John O'Brien


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background A limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies. Aims To investigate changes in CBF using arterial spin labelling (ASL) magnetic resonance imaging (MRI) in people with late-life depression and in a similarly aged healthy control group. Method Sixty-eight participants (30 healthy individuals, 38 with depression) underwent ASL and T-1-weighted MRI scanning. For each individual, regional estimates of separate grey and white matter CBF were obtained. Group differences in CBF and their associations with clinical features were examined. Results Significant increases were observed in white matter CBF in patients with depression relative to the control group (F-1.65=9.7, P=0.003). Grey matter CBE in lateral frontal, medial frontal, cingulate, central and parietal regions did not significantly differ between groups (F-1,F-65 <= 2.1, P >= 0.2). A significant correlation was found between white matter CBF and Montgomery-Asberg Depression Rating Scale (MADRS) scores in depression (r'=-0.42, P=0.03). Further analyses revealed that compared with controls, significant elevation of white matter CBF was apparent in participants whose depression was in remission (n=21, MADRS <= 10, P=0.001) but not in those with current depression (n=17, MADRS >= 11, P=0.80). Conclusions Findings suggest a compensatory response to white matter pathological change or a response to (or a predictor of) successful antidepressant treatment, perhaps by facilitating neurotransmission in specific circuits and so reducing depressive symptoms.

Publication metadata

Author(s): Colloby SJ, Firbank MJ, He JB, Thomas AJ, Vasudev A, Parry SW, O'Brien JT

Publication type: Article

Publication status: Published

Journal: British Journal of Psychiatry

Year: 2012

Volume: 200

Issue: 2

Pages: 150-155

Print publication date: 22/12/2011

ISSN (print): 0007-1250

ISSN (electronic): 1472-1465

Publisher: Royal College of Psychiatrists


DOI: 10.1192/bjp.bp.111.092387


Altmetrics provided by Altmetric