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Low serum mannose-binding lectin level is not associated with disease severity in non-cystic fibrosis bronchiectasis

Lookup NU author(s): Dr Jim Macfarlane, Dr Hannah Jary, Dr Katy Hester, Dr Gavin Spickett, Professor Anthony De SoyzaORCiD


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Deficiency of mannose-binding lectin (MBL), a serum protein involved in killing and promoting phagocytosis of pathogens, is associated with respiratory infection and disease progression in a number of acute and chronic lung diseases, including cystic fibrosis (CF)- associated bronchiectasis. No such association has been studied in non-CF bronchiectasis (nCF-Br). One hundred and thirty-three adult patients with nCF-Br were studied. Serum MBL levels were measured and deficiency defined using two cut-off levels, i.e. MBL ≤100 ng/ml and ≤600 ng/ml. Parameters of severity included lung function impairment, annual exacerbation and hospital admission rates, breathlessness, and Pseudomonas aeruginosa and Haemophilus influenzae infection rates. The incidence of MBL deficiency using cut-off levels of 100 ng/ml and 600 ng/ml was 10% and 26% respectively, similar to rates seen in the general population. There was no significant difference in mean FEV1% predicted between MBL deficient and sufficient patients at both cut-off levels (≤100 ng/ml: 63.8% vs. 64.6%, P = 0.91; ≤ 600 ng/ml: 66.5% vs. 63.9%, P = 0.56). In addition, exacerbation/hospital admission rates, symptoms of breathlessness and isolation/colonisation rates with P. aeruginosa and H. influenzae were similar in both groups at both cut-off levels. In conclusion, MBL deficiency is not associated with markers of disease severity in patients with nCF-Br.

Publication metadata

Author(s): Macfarlane JG, Jary H, Hester KL, McAlinden P, Wake J, Small T, Walton KE, Spickett G, De Soyza A

Publication type: Article

Publication status: Published

Journal: Innate Immunity

Year: 2012

Volume: 18

Issue: 6

Pages: 787-792

Print publication date: 01/03/2012

ISSN (print): 1753-4259

ISSN (electronic): 1753-4267

Publisher: Sage Publications Ltd.


DOI: 10.1177/1753425912440472

PubMed id: 22382779


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Funder referenceFunder name
DRF-2012-05-149Department of Health