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Assessment of collagenase activity in cartilage

Lookup NU author(s): Emeritus Professor Tim Cawston


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Assay of collagenase activity involves the use of radiolabeled collagen. Stimulation of cartilage with proinflammatory cytokines results in the upregulation of collagenases and the subsequent release of degraded collagen fragments. These enzymes can be localized in both osteoarthritic and rheumatoid arthritis cartilage and synovial tissues.

Publication metadata

Author(s): Cawston TE, Morgan TG

Editor(s): Cope, AP

Publication type: Book Chapter

Publication status: Published

Book Title: Arthritis Research

Year: 2007

Volume: 135

Pages: 211-226

Edition: 1st

Series Title: Methods in Molecular Medicine

Publisher: Humana Press, Inc.

Place Published: US


DOI: 10.1007/978-1-59745-401-8_13

Notes: ISSN: 1543-1894 (Print) 1940-6037 (Online) Online ISBN: 9781597454018

Library holdings: Search Newcastle University Library for this item

ISBN: 9781588293442