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Post-stroke dementia: the contribution of thalamus and basal ganglia changes

Lookup NU author(s): Marcos Lopes, Dr Michael FirbankORCiD, Michelle Widdrington, Professor Andrew BlamireORCiD, Professor Raj KalariaORCiD, Professor John O'Brien


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Background: The neurobiological basis of increased risk of dementia in stroke patients is unclear, though there are several related pathological changes, including white matter hyperintensities (WMH), and medial temporal atrophy. Subcortical gray matter structures have also been implicated in dementia resulting from vascular pathology, particularly vascular dementia. This study aimed to investigate the contribution of changes in subcortical gray matter structures to post-stroke dementia (PSD). Methods: T1- and T2-weighted images and T2-weighted fluid-attenuated inversion recovery (FLAIR) images were obtained on a 3-Tesla magnetic resonance (MR) system, in four groups aged over 75 years: post-stroke with dementia (PSD; 8), post-stroke no dementia (PSnoD; 33), Alzheimer's disease (AD; 26) and controls (30). Automated software was used to measure the volume of thalamus, putamen, caudate nucleus, and hippocampus as well as total WMH volume. The number of subcortical lacunes was also counted. Results: The number of caudate lacunes was higher in the PSnoD group, compared with AD (p = 0.029) and controls (p = 0.019). The putamen volume was smaller in the stroke and AD groups, when compared with controls. In the whole stroke group, putamen lacunes were correlated with impairment in memory (Rey test; p = -0.365; p = 0.031), while WMH and hippocampal volume both correlated with global dysfunction. Conclusion: Our findings implicate a variety of neurobiological substrates of dementia, such as small vessel disease and Alzheimer pathology, which develop after stroke in an old older population, with a contribution from subcortical brain structures.

Publication metadata

Author(s): Lopes MA, Firbank MJ, Widdrington M, Blamire AM, Kalaria RN, O'Brien JT

Publication type: Article

Publication status: Published

Journal: International Psychogeriatrics

Year: 2012

Volume: 24

Issue: 4

Pages: 568-576

Print publication date: 12/12/2011

ISSN (print): 1041-6102

ISSN (electronic): 1741-203X

Publisher: Cambridge University Press


DOI: 10.1017/S1041610211002195


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Funder referenceFunder name
CNPQ (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico), Brasil
Alzheimer's Research Trust (UK)
UK NIHR Biomedical Research Centre for Ageing and Age Related Diseases
G0500247Medical Research Council (UK)