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Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging

Lookup NU author(s): Professor Ruth Plummer


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Many therapeutic approaches to cancer affect the tumour vasculature, either indirectly or as a direct target. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has become an important means of investigating this action, both pre-clinically and in early stage clinical trials. For such trials, it is essential that the measurement process (i.e. image acquisition and analysis) can be performed effectively and with consistency among contributing centres. As the technique continues to develop in order to provide potential improvements in sensitivity and physiological relevance, there is considerable scope for between-centre variation in techniques. A workshop was convened by the Imaging Committee of the Experimental Cancer Medicine Centres (ECMC) to review the current status of DCE-MRI and to provide recommendations on how the technique can best be used for early stage trials. This review and the consequent recommendations are summarised here. Key Points aEuro cent Tumour vascular function is key to tumour development and treatment aEuro cent Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can assess tumour vascular function aEuro cent Thus DCE-MRI with pharmacokinetic models can assess novel treatments aEuro cent Many recent developments are advancing the accuracy of and information from DCE-MRI aEuro cent Establishing common methodology across multiple centres is challenging and requires accepted guidelines.

Publication metadata

Author(s): Leach MO, Morgan B, Tofts PS, Buckley DL, Huang W, Horsfield MA, Chenevert TL, Collins DJ, Jackson A, Lomas D, Whitcher B, Clarke L, Plummer R, Judson I, Jones R, Alonzi R, Brunner T, Koh DM, Murphy P, Waterton JC, Parker G, Graves MJ, Scheenen TWJ, Redpath TW, Orton M, Karczmar G, Huisman H, Barentsz J, Padhani A, Expt Canc Med Ctr Imaging Network

Publication type: Article

Publication status: Published

Journal: European Radiology

Year: 2012

Volume: 22

Issue: 7

Pages: 1451-1464

Print publication date: 07/05/2012

ISSN (print): 0938-7994

ISSN (electronic): 1432-1084

Publisher: Springer


DOI: 10.1007/s00330-012-2446-x


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