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Lookup NU author(s): Professor Waldemar Vollmer
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The cell wall of Streptococcus pneumoniae contains an unusually complex wall teichoic acid (WTA), which has identical repeating units as the membrane-anchored lipoteichoic acid (LTA). Both polymers share a common cytoplasmic pathway of precursor synthesis, but several TA enzymes have remained elusive. Bioinformatic analysis of the genome of various pneumococcal strains, including choline-independent mutant strains, has allowed us to identify the missing TA genes. We present here the deduced complete pathways of WTA and LTA synthesis in S. pneumoniae and point to the variations occurring in different pneumococcal strains and in closely related species such as Streptococcus oralis and Streptococcus mitis.
Author(s): Denapaite D, Bruckner R, Hakenbeck R, Vollmer W
Publication type: Article
Publication status: Published
Journal: Microbial Drug Resistance
Print publication date: 20/03/2012
ISSN (print): 1076-6294
ISSN (electronic): 1931-8448
Publisher: Mary Ann Liebert, Inc.
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