Toggle Main Menu Toggle Search

Open Access padlockePrints

Understanding the impact of deep brain stimulation on ambulatory activity in advanced Parkinson's disease

Lookup NU author(s): Professor Lynn RochesterORCiD, Dr Susan Lord, Professor David Burn


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Whilst deep brain stimulation of the subthalamic nucleus (DBS-STN) improves the motor symptoms of Parkinson's disease (PD), its effect on daily activity is unknown. We aimed to quantify changes in ambulatory activity following DBS-STN in advanced PD using novel accelerometry based measures that describe changes to the volume and pattern of walking. Seventeen participants with advanced PD were measured over a 7-day period using an activPAL ((TM)) activity monitor. Data were collected 6 weeks before and 6 months after surgery and included measures that describe the volume and pattern of ambulatory activity (number of steps per day, accumulation, diversity and variability of walking time), alongside standard measures for disease severity, freezing of gait, gait speed, and extended activities of daily living. Activity outcomes were compared pre- and 6 months post-surgery using linear mixed models and correlated with standard outcomes. The results of this study are despite significant improvements in motor symptoms after surgery, the volume of ambulatory activity (total number of steps per day) did not change (P = 0.468). However, significant increases in length and variability of walking bouts emerged, suggesting improvements in diversity and flexibility of walking patterns. Motor severity and extended activities of daily living scores were significantly correlated with walking bout variability but not with volume of walking. Thus, the conclusions are reduction in motor symptom severity after DBS-STN translated into selective improvements in daily activity. Novel measures derived from accelerometry provide a discrete measure of performance and allow closer interpretation of the impact of DBS-STN on real-world activity.

Publication metadata

Author(s): Rochester L, Chastin SFM, Lord S, Baker K, Burn DJ

Publication type: Article

Publication status: Published

Journal: Journal of Neurology

Year: 2012

Volume: 259

Issue: 6

Pages: 1081-1086

Print publication date: 15/11/2011

ISSN (print): 0340-5354

ISSN (electronic): 1432-1459

Publisher: Springer


DOI: 10.1007/s00415-011-6301-9


Altmetrics provided by Altmetric


Funder referenceFunder name
UK NIHR Biomedical Research Centre for Ageing and Age
8048Parkinson's UK