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Mitochondrial pharma-Q-genomics: Targeting the OXPHOS cytochrome b

Lookup NU author(s): Dr Aurora Gomez Duran

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Abstract

Genetic variation in human cytochrome b generates structurally different coenzyme Q binding pockets, affects the coupling efficiency of the oxidative phosphorylation system and susceptibility to different medical conditions. As modification of coupling efficiency has already been shown to have therapeutic interest, these structural differences might be used to develop new drugs and allow for personalized medicine, giving rise to a new field: mitochondrial pharmacogenomics.

Publication metadata

Author(s): Gómez-Durán A, Pacheu-Grau D, López-Pérez MJ, Montoya J, Ruíz-Pesini E

Publication type: Article

Publication status: Published

Journal: Drug Discovery Today

Year: 2011

Volume: 16

Issue: 5-6

Pages: 176-180

Print publication date: 01/03/2011

ISSN (print): 1359-6446

ISSN (electronic): 1878-5832

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.drudis.2010.11.010

DOI: 10.1016/j.drudis.2010.11.010

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