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How to use... alkaline phosphatase in neonatology

Lookup NU author(s): Dr Robert Tinnion, Professor Nicholas EmbletonORCiD


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Alkaline phosphatase (ALP) is regularly measured in clinical practice. Changes in serum levels are observed in a number of clinical conditions. In neonatology, it has been proposed as a useful marker for both a diagnosis and an indication of the severity of metabolic bone disease (MBD) in infants born preterm. Nutritional practices, aimed at reducing the occurrence or severity of MBD, have led to ALP being proposed as a stand-alone means of monitoring treatment. The current evidence does not support this use: ALP only achieves usefulness in a diagnostic and monitoring capacity when combined with other serum and imaging techniques.

Publication metadata

Author(s): Tinnion RJ, Embleton ND

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood: Education and Practice Edition

Year: 2012

Volume: 97

Issue: 4

Pages: 157-163

Print publication date: 03/07/2012

ISSN (print): 1743-0585

ISSN (electronic): 1743-0593

Publisher: BMJ Group


DOI: 10.1136/archdischild-2012-301633


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