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Non-lytic expulsion/exocytosis of Candida albicans from macrophages

Lookup NU author(s): Professor Janet Quinn


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Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells. (C) 2012 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Bain JM, Lewis LE, Okai B, Quinn J, Gow NAR, Erwig LP

Publication type: Article

Publication status: Published

Journal: Fungal Genetics and Biology

Year: 2012

Volume: 49

Issue: 9

Pages: 677-678

Print publication date: 01/09/2012

ISSN (print): 1087-1845

ISSN (electronic): 1096-0937

Publisher: Academic Press


DOI: 10.1016/j.fgb.2012.01.008


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Funder referenceFunder name
075470Wellcome Trust
080088Wellcome Trust
089930Wellcome Trust
SCD/03Chief Scientist Office