Toggle Main Menu Toggle Search

Open Access padlockePrints

Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture

Lookup NU author(s): Dr Kheng-Lim GohORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Scaling relationships have been formulated to investigate the influence of collagen fibril diameter (D) on age-related variations in the strain energy density of tendon. Transmission electron microscopy was used to quantify D in tail tendon from 1.7- to 35.3-mo-old (C57BL/6) male mice. Frequency histograms ofD for all age groups were modeled as two normally distributed subpopulations with smaller (DD1) and larger (DD2) mean Ds, respectively. Both DD1 and DD2increase from 1.6 to 4.0 mo but decrease thereafter. From tensile tests to rupture, two strain energy densities were calculated: 1) uE [from initial loading until the yield stress (σY)], which contributes primarily to tendon resilience, and 2) uF[from σY through the maximum stress (σU) until rupture], which relates primarily to resistance of the tendons to rupture. As measured by the normalized strain energy densities uEY and uFU, both the resilience and resistance to rupture increase with increasing age and peak at 23.0 and 4.0 mo, respectively, before decreasing thereafter. Multiple regression analysis reveals that increases in uEY(resilience energy) are associated with decreases in DD1 and increases in DD2, whereas uFU (rupture energy) is associated with increases in DD1 alone. These findings support a model where age-related variations in tendon resilience and resistance to rupture can be directed by subtle changes in the bimodal distribution of Ds.

Publication metadata

Author(s): Goh KL, Holmes DF, Lu Y-H, Purslow PP, Kadler KE, Bechet D, Wess TJ

Publication type: Article

Publication status: Published

Journal: Journal of Applied Physiology

Year: 2012

Volume: 113

Issue: 6

Pages: 878-888

Print publication date: 26/07/2012

Date deposited: 28/09/2014

ISSN (print): 8750-7587

ISSN (electronic): 1522-1601

Publisher: American Physiological Society


DOI: 10.1152/japplphysiol.00258.2012


Altmetrics provided by Altmetric


Funder referenceFunder name
Collier Charitable Trust
091840/Z/10/ZWellcome Trust
5.03.07Merlion-France Programme under the French Ministere des Affaires Etrangeres et Europeennes
QLK6-CT-2001-00175European Union