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The mystery of mitochondrial RNases

Lookup NU author(s): Dr Francesco Bruni, Dr Pasqua Gramegna, Professor Robert Lightowlers, Professor Zofia Chrzanowska-LightowlersORCiD


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The central dogma states that DNA is transcribed to generate RNA and that the mRNA components are then translated to generate proteins; a simple statement that completely belies the complexities of gene expression. Post-transcriptional regulation alone has many points of control, including changes in the stability, translatability or susceptibility to degradation of RNA species, where both cis- and transacting elements will play a role in the outcome. The present review concentrates on just one aspect of this complicated process, which ultimately regulates the protein production in cells, or more specifically what governs RNA catabolism in a particular subcompartment of human cells: the mitochondrion.

Publication metadata

Author(s): Bruni F, Gramegna P, Lightowlers RN, Chrzanowska-Lightowlers ZMA

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2012

Volume: 40

Issue: 4

Pages: 865-869

Print publication date: 01/08/2012

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.


DOI: 10.1042/BST20120022


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Funder referenceFunder name
074454/Z/04/ZWellcome Trust
BB/F011520/1Biotechnology and Biological Sciences Research Council