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Frequency, prevalence, incidence and risk factors associated with visual hallucinations in a sample of patients with Parkinson's disease: a longitudinal 4-year study

Lookup NU author(s): Dr Grant Gibson, Professor David Burn

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Abstract

Objective To examine the prevalence, incidence and risk factors associated with visual hallucinations (VHs) amongst people suffering from Parkinson's disease (PD). Methods We recruited 513 patients with PD from movement disorder and PD clinics within three sites in the UK. Patients were interviewed using a series of standardised clinical rating scales at baseline, 12, 24 and 36 months. Data relating to VHs were collected using the North-East Visual Hallucinations Interview. Prevalence rates for VHs at each assessment were recorded. Associations were determined using multiple regression analysis. Results Cross-sectional prevalence rates for VHs at baseline, 12, 24 and 36 months indicated VHs in approximately 50% of patients. A cumulative frequency of 82.7% of cases at the end of the study period exhibited VHs. The incidence rate for VHs was 457 cases per 1000 population. Longer disease duration, greater impairment in activities of daily living and higher rates of anxiety were most commonly associated with VHs. No factors predictive of VHs could be ascertained. Conclusions When examined longitudinally, VHs affect more patients than is commonly assumed in cross-sectional prevalence studies. Clinicians should routinely screen for VHs throughout the disease course. Disease duration, impairment in activities of daily living and anxiety presented as co-morbidities associated with VHs in PD, and therefore those presenting with VHs should be screened for anxiety disorder and vice versa

Publication metadata

Author(s): Gibson G, Mottram P, Burn D, Hindle J, Landau S, Samuel M, Hurt C, Brown R, Wilson K

Publication type: Article

Publication status: Published

Journal: International Journal of Geriatric Psychiatry

Year: 2013

Volume: 28

Issue: 6

Pages: 626-631

Print publication date: 01/06/2013

Online publication date: 28/08/2012

Acceptance date: 18/07/2012

ISSN (print): 0885-6230

ISSN (electronic): 1099-1166

Publisher: John Wiley & Sons Ltd.

URL: http://dx.doi.org/10.1002/gps.3869

DOI: 10.1002/gps.3869

PubMed id: 22927195

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