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Negative regulation of hypoxic responses via induced Reptin methylation

Lookup NU author(s): Dr Jo Lee, Dr Olivier Binda

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Abstract

Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.


Publication metadata

Author(s): Lee JS, Kim Y, Kim IS, Kim B, Choi HJ, Lee JM, Shin HJ, Kim JH, Kim JY, Seo SB, Lee H, Binda O, Gozani O, Semenza GL, Kim M, Kim KI, Hwang D, Baek SH

Publication type: Article

Publication status: Published

Journal: Molecular Cell

Year: 2010

Volume: 39

Issue: 1

Pages: 71-85

Print publication date: 09/07/2010

ISSN (print): 1097-2765

ISSN (electronic): 1097-4164

Publisher: Elsevier Inc.

URL: http://dx.doi.org/10.1016/j.molcel.2010.06.008

DOI: 10.1016/j.molcel.2010.06.008

PubMed id: 20603076


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