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Voice outcomes after concurrent chemoradiotherapy for advanced nonlaryngeal head and neck cancer: A prospective study

Lookup NU author(s): Professor Vinidh Paleri, Professor Paul Carding, Dr Sanjoy Chatterjee, Dr Charles Kelly, Emerita Professor Janet Wilson, Andrew Welch, Dr Michael Drinnan

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Abstract

Background: The voice impact of treatment for nonlaryngeal head and neck primary sites remains unknown. Methods: We conducted a prospective study of a consecutive sample of patients undergoing chemoradiation for nonlaryngeal head and neck cancer. The Voice Symptom Scale (VoiSS) was completed, and voice recordings were made at 3 time-points. Results: Of 42 recruited patients, 34 completed the measures before and in the early posttreatment phase (mean 16.5 weeks), while 21 patients were assessed at the final time-point (mean, 20.4 months). VoiSS scores showed statistically significant progressive deterioration in the total score (p = .02) and impairment subscale (p < .0001) through to the final assessment. Acoustic measures and perceptual ratings deteriorated significantly (p < .001) in the early posttreatment weeks and improved at the final assessment, but not to the baseline. Interrater agreement was excellent for expert measures. Conclusion To the best of our knowledge, this is the first prospective study to show that chemoradiation therapy for nonlaryngeal head and neck cancer has a significant effect on the patients' self-reported voice quality, even in the long term.


Publication metadata

Author(s): Paleri V, Carding P, Chatterjee S, Kelly C, Wilson JA, Welch A, Drinnan M

Publication type: Article

Publication status: Published

Journal: Head and Neck

Year: 2012

Volume: 34

Issue: 12

Pages: 1747-1752

Print publication date: 01/12/2012

ISSN (print): 1043-3074

ISSN (electronic):

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1002/hed.22003

DOI: 10.1002/hed.22003


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