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Does vascular pathology contribute to Alzheimer changes?

Lookup NU author(s): Professor Raj KalariaORCiD, Dr Rufus Akinyemi, Dr Masafumi Ihara


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In recent years there has been increased interest in whether vascular disease contributes to Alzheimer's disease (AD). This review considers how modifiable risk factors such as hypertension, atherosclerosis, diabetes, dyslipidaemia and adiposity may impact on vascular structure and function to promote neurodegenerative processes and instigate AD. The presence of vascular pathology involving arterial stiffness, arteriolosclerosis, endothelial degeneration and blood brain barrier dysfunction leads to chronic cerebral hypoperfusion. Pathological changes in human brain and animal studies suggest cerebral hypoperfusion which in turn induces several features of AD pathology including selective brain atrophy, white matter changes and accumulation of abnormal proteins such as amyloid beta. Cerebral pathological changes may be further modified by genetic factors such as the apoliopoprotein E epsilon 4 allele. Although tau hyperphosphorylation and tangle formation still needs robust explanation further support for the notion that vascular pathology influences AD changes is provided by the evidence that interventions which improve vascular function attenuate AD pathology. (c) 2012 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Kalaria RN, Akinyemi R, Ihara M

Publication type: Article

Publication status: Published

Journal: Journal of the Neurological Sciences

Year: 2012

Volume: 322

Issue: 1-2

Pages: 141-147

Print publication date: 01/11/2012

ISSN (print): 0022-510X

ISSN (electronic): 1878-5883

Publisher: Elsevier BV


DOI: 10.1016/j.jns.2012.07.032


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Funder referenceFunder name
International Brain Research Organisation (IBRO) Research Fellowship
Alzheimer's Research Trust (UK)
G0500247Medical Research Council (UK)
G0700718Medical Research Council (UK)
NS054047US National Institutes of Health (NINDS) grant