Toggle Main Menu Toggle Search

Open Access padlockePrints

Identification and characterisation of STMN4 and ROBO2 gene involvement in neuroblastoma cell differentiation

Lookup NU author(s): Nidal Boulos, Dr Michael Tilby, Professor Deborah Tweddle, Professor John Lunec


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


To better understand neuroblastoma differentiation, we used microarray analysis to identify common gene expression changes from three differentiation models. This revealed STMN4 and ROBO2 to be consistently up-regulated in differentiated neuroblastoma cells induced by chromosome 1 transfer, MYCN knockdown, and 9-cis retinoic acid (9cRA). Furthermore, stable expression of transfected STMN4 or ROBO2 induced differentiation in IMR-32 cells. STMN4 and ROBO2 expression also increased in other 9cRA-induced differentiated neuroblastoma cell lines. Of clinical importance is that neuroblastoma patients with higher tumour mRNA expression of STMN4 and ROBO2 had better progression-free survival. This study highlights the importance of STMN4 and ROBO2 during neuroblastoma differentiation. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Sung PJ, Boulos N, Tilby MJ, Andrews WD, Newbold RF, Tweddle DA, Lunec J

Publication type: Article

Publication status: Published

Journal: Cancer Letters

Year: 2013

Volume: 328

Issue: 1

Pages: 168-175

Print publication date: 01/01/2013

ISSN (print): 0304-3835

ISSN (electronic): 1872-7980

Publisher: Elsevier


DOI: 10.1016/j.canlet.2012.08.015


Altmetrics provided by Altmetric


Funder referenceFunder name
Cancer Research UK
North of England Children's Cancer Research Fund
Overseas Research Award
UK Department of Health
Wellcome trust
089775Wellcome Trust