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Synaptic proteins and choline acetyltransferase loss in visual cortex in dementia with Lewy bodies

Lookup NU author(s): Dr Elizabeta Mukaetova-Ladinska, Dr Alina Andras, Joan Milne, Zeinab Abdel-All, Dr Iwo Bohr, Dr Evelyn Jaros, Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry, Professor Raj KalariaORCiD, Professor Ian McKeith


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Functional neuroimaging studies have consistently reported abnormalities in the visual cortex in patients with dementia with Lewy bodies (DLB), but their neuropathologic substrates are poorly understood. We analyzed synaptic proteins and choline acetyltransferase (ChAT) in the primary (BA17) and association (BAs18/19) visual cortex in DLB and similar aged control and Alzheimer disease (AD) subjects. We found lower levels of synaptophysin, syntaxin, SNAP-25, and gamma-synuclein in DLB subjects versus both aged control (68%-78% and 27%-72% for BA17 and BAs18/19, respectively) and AD cases (54%-67% and 10%-56% for BA17 and BAs18/19, respectively). The loss in ChAT activity in DLB cases was also greater in BA17 (72% and 87% vs AD and control values, respectively) than in BAs18/19 (52% and 65% vs AD and control groups, respectively). The observed synaptic and ChAT changes in the visual cortices were not associated with tau or A-amyloid pathology in the occipital or the frontal, temporal, and parietal neocortex. However, the neocortical densities of LBs, particular those in BA17 and BAs18/19, correlated with lower synaptic and ChAT levels in these brain areas. These findings draw attention to molecular changes within the primary visual cortex in DLB and correlate with the neuroimaging findings within the occipital lobe in patients with this disorder.

Publication metadata

Author(s): Mukaetova-Ladinska EB, Andras A, Milne J, Abdel-All Z, Bohr I, Jaros E, Perry RH, Honer WG, Cleghorn A, Doherty J, McIntosh G, Perry EK, Kalaria RN, McKeith IG

Publication type: Article

Publication status: Published

Journal: Journal of Neuropathology and Experimental Neurology

Year: 2013

Volume: 72

Issue: 1

Pages: 53-60

Print publication date: 01/01/2013

ISSN (print): 0022-3069

ISSN (electronic): 1554-6578

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/NEN.0b013e31827c5710


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