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Multivariate spatial covariance analysis of 99mTc-exametazime SPECT images in dementia with Lewy bodies and Alzheimer’s disease: utility in differential diagnosis

Lookup NU author(s): Dr Sean Colloby, Professor John-Paul TaylorORCiD, Dr Christopher Davison, Dr James LloydORCiD, Dr Michael FirbankORCiD, Professor Ian McKeith, Professor John O'Brien

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Abstract

We examined 99mTc-exametazime brain blood flow single-photon emission computed tomography (SPECT) images using a spatial covariance analysis (SCA) approach to assess its diagnostic value in distinguishing dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD). Voxel SCA was simultaneously applied to a set of preprocessed images (AD, n=40; DLB, n=26), generating a series of eigenimages representing common intercorrelated voxels in AD and DLB. Linear regression derived a spatial covariance pattern (SCP) that discriminated DLB from AD. To investigate the diagnostic value of the model SCP, the SCP was validated by applying it to a second, independent, AD and DLB cohort (AD, n=34; DLB, n=29). Mean SCP expressions differed between AD and DLB (F1,64=36.2, P<0.001) with good diagnostic accuracy (receiver operating characteristic (ROC) curve area 0.87, sensitivity 81%, specificity 88%). Forward application of the model SCP to the independent cohort revealed similar differences between groups (F1,61=38.4, P<0.001), also with good diagnostic accuracy (ROC 0.86, sensitivity 80%, specificity 80%). Multivariate analysis of blood flow SPECT data appears to be robust and shows good diagnostic accuracy in two independent cohorts for distinguishing DLB from AD.


Publication metadata

Author(s): Colloby SJ, Taylor J-P, Davison CM, Lloyd JJ, Firbank MJ, McKeith IG, O'Brien JT

Publication type: Article

Publication status: Published

Journal: Journal of Cerebral Blood Flow & Metabolism

Year: 2013

Volume: 33

Issue: 4

Pages: 612-618

Print publication date: 30/01/2013

ISSN (print): 0271-678X

ISSN (electronic): 1559-7016

Publisher: International Society for Cerebral Blood Flow & Metabolism

URL: http://dx.doi.org/10.1038/jcbfm.2013.2

DOI: 10.1038/jcbfm.2013.2


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Funding

Funder referenceFunder name
National Institute for Health Research (NIHR) Research for Public Benefit
NIHR Dementia Biomedical Research Unit at Cambridge University Hospitals NHS Foundation Trust
Wellcome Trust
Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle University
NIHR Newcastle Biomedical Research Centre in Ageing and Chronic Disease
University of Cambridge
G9817682Medical Research Council UK

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