Toggle Main Menu Toggle Search

Open Access padlockePrints

Evidence of an inhibitory restraint of seizure activity in humans

Lookup NU author(s): Professor Andrew Trevelyan



The location and trajectory of seizure activity is of great importance, yet our ability to map such activity remains primitive. Recently, the development of multi-electrode arrays for use in humans has provided new levels of temporal and spatial resolution for recording seizures. Here, we show that there is a sharp delineation between areas showing intense, hypersynchronous firing indicative of recruitment to the seizure, and adjacent territories where there is only low-level, unstructured firing. Thus, there is a core territory of recruited neurons and a surrounding 'ictal penumbra'. The defining feature of the 'ictal penumbra' is the contrast between the large amplitude EEG signals and the low-level firing there. Our human recordings bear striking similarities with animal studies of an inhibitory restraint, indicating that they can be readily understood in terms of this mechanism. These findings have important implications for how we localize seizure activity and map its spread.

Publication metadata

Author(s): Schevon CA, Weiss S, McKhann G, Goodman RR, Yuste R, Emerson RG, Trevelyan AJ

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2012

Volume: 3

Print publication date: 11/09/2012

Date deposited: 18/02/2013

ISSN (electronic): 2041-1723

Publisher: Nature Press


DOI: 10.1038/ncomms2056

PubMed id: 22968706


Altmetrics provided by Altmetric


Funder referenceFunder name
Epilepsy Foundation of America
Epilepsy Research UK
National Institutes of Health
Kavli Institute for Brain Science