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Lookup NU author(s): Parimala Saminathan,
Dr Ross Harrington,
Emeritus Professor Bill CleggORCiD,
Dr Michael HallORCiD
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2,2,2-Trichloro-1-aryl-ethanones undergo high yielding reductions to the corresponding 2,2-dichloro-1-aryl-ethanones in the presence of RMgX. A single electron transfer mechanism for the reaction is proposed based on trapping experiments. Reaction of the intermediate enolates with a range of electrophiles is described, providing a convenient route to substituted α,α-dichloro-β-hydroxy-ketones and related molecules.
Author(s): Essa AH, Lerrick RI, Tuna F, Harrington RW, Clegg W, Hall MJ
Publication type: Article
Publication status: Published
Journal: Chemical Communications
Print publication date: 19/02/2013
ISSN (print): 1359-7345
ISSN (electronic): 1364-548X
Publisher: RSC Publications
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