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Efficient Multigram Syntheses of Air-Stable, Chiral Primary Phosphine Ligand Precursors via Palladium-Catalyzed Phosphonylation of Aryltriflates

Lookup NU author(s): Arne Ficks, Connor Sibbald, Dr Ross Harrington, Emeritus Professor Bill CleggORCiD, Dr Lee HighamORCiD


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Air-stable, chiral primary phosphines have been synthesized on a multigram scale. The key synthetic step is an optimized palladium-catalyzed phosphonylation reaction of aryltriflates, which opens up a valuable synthetic route to a chiral scaffold that is easily derivatized into novel phosphines.

Publication metadata

Author(s): Ficks A, Sibbald C, Ojo S, Harrington RW, Clegg W, Higham LJ

Publication type: Article

Publication status: Published

Journal: Synthesis

Year: 2013

Volume: 45

Issue: 2

Pages: 265-271

Print publication date: 01/01/2013

ISSN (print): 0039-7881

ISSN (electronic): 1437-210X

Publisher: Georg Thieme Verlag


DOI: 10.1055/s-0032-1316825


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