Toggle Main Menu Toggle Search

Open Access padlockePrints

Dorsal rather than ventral visual pathways discriminate freezing status in Parkinson's disease

Lookup NU author(s): Dr Susan Lord, Dr Neil Archibald, Dr Urs Mosimann, Professor David Burn, Professor Lynn Rochester


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background: Although visuospatial deficits have been linked with freezing of gait (FOG) in Parkinson's disease (PD), the specific effects of dorsal and ventral visual pathway dysfunction on FOG is not well understood. Method: We assessed visuospatial function in FOG using an angle discrimination test (dorsal visual pathway bias) and overlapping figure test (ventral visual pathway bias), and recorded overall response time, mean fixation duration and dwell time. Covariate analysis was conducted controlling for disease duration, motor severity, contrast sensitivity and attention with Bonferroni adjustments for multiple comparisons. Results: Twenty seven people with FOG, 27 people without FOG and 24 controls were assessed. Average fixation duration during angle discrimination distinguished freezing status: [F(1, 43) = 4.77 p < 0.05] (1-way ANCOVA). Conclusion: Results indicate a preferential dysfunction of dorsal occipito-parietal pathways in FOG, independent of disease severity, attentional deficit, and contrast sensitivity. (c) 2012 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Mosimann U; Archibald N; Burn D; Rochester L; Lord S

Publication type: Article

Publication status: Published

Journal: Parkinsonism & Related Disorders

Year: 2012

Volume: 18

Issue: 10

Pages: 1094-1096

Print publication date: 01/12/2012

ISSN (print): 1353-8020

ISSN (electronic): 1873-5126

Publisher: Elsevier Ltd


DOI: 10.1016/j.parkreldis.2012.05.016


Altmetrics provided by Altmetric


Funder referenceFunder name
Haag Streit Foundation
Medical Research Council
Wellcome Trust
Foundation of Traffic Safety
Gottfried and Julia Bangerter Foundation
Michael J. Fox Foundation
National Institute for Health Research
Progressive Supranuclear Palsy (Europe) Association
UK NIHR Biomedical Research Centre for Ageing and Age-related disease award
07/H0902/47Parkinson's UK