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Lookup NU author(s): Dr Neil Archibald,
Professor David Burn,
Professor Lynn Rochester
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Background: Although visuospatial deficits have been linked with freezing of gait (FOG) in Parkinson's disease (PD), the specific effects of dorsal and ventral visual pathway dysfunction on FOG is not well understood. Method: We assessed visuospatial function in FOG using an angle discrimination test (dorsal visual pathway bias) and overlapping figure test (ventral visual pathway bias), and recorded overall response time, mean fixation duration and dwell time. Covariate analysis was conducted controlling for disease duration, motor severity, contrast sensitivity and attention with Bonferroni adjustments for multiple comparisons. Results: Twenty seven people with FOG, 27 people without FOG and 24 controls were assessed. Average fixation duration during angle discrimination distinguished freezing status: [F(1, 43) = 4.77 p < 0.05] (1-way ANCOVA). Conclusion: Results indicate a preferential dysfunction of dorsal occipito-parietal pathways in FOG, independent of disease severity, attentional deficit, and contrast sensitivity. (c) 2012 Elsevier Ltd. All rights reserved.
Author(s): Mosimann U; Archibald N; Burn D; Rochester L; Lord S
Publication type: Article
Publication status: Published
Journal: Parkinsonism & Related Disorders
Print publication date: 01/12/2012
ISSN (print): 1353-8020
ISSN (electronic): 1873-5126
Publisher: Elsevier Ltd
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