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Ziprasidone - Not Haloperidol - Induces more de-novo Neurogenesis of Adult Neural Stem Cells Derived from Murine Hippocampus

Lookup NU author(s): Professor Heinz Grunze

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Abstract

Introduction: Here, we present a stem-cell based study on the de-novo generation of beta-III-tubulin-positive neurons after treatment with the classic antipsychotic drug haloperidol or after treatment with the second-generation antipsychotic (SGA) ziprasidone. Methods: Adult neural stem cells (ANSC) dissociated from the adult mouse hippocampus were expanded in cell culture with basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF). ANSC differentiated upon withdrawal of EGF and bFGF. Results and Discussion: Ziprasidone generated significantly more beta-III-tubulin-positive neurons than haloperidol during the differentiation of adult neural stem cells isolated from murine hippocampus (ANSC). We assume that this net increase in neurogenesis by ziprasidone relies on this drug's 5-HT1A receptor affinity, which is not present in the haloperidol molecule, since the inactivation by WAY100621 impeded this process. These data could possibly suggest a clinical relevance for studying antipsychotic drugs in the stem cell paradigm employed in this study.

Publication metadata

Author(s): Benninghoff J, Grunze H, Schindler C, Genius J, Schloesser RJ, van der Ven A, Dehning S, Wiltfang J, Moller HJ, Rujescu D

Publication type: Article

Publication status: Published

Journal: Pharmacopsychiatry

Year: 2013

Volume: 46

Issue: 1

Pages: 10-15

Print publication date: 01/01/2013

ISSN (print): 0176-3679

ISSN (electronic):

Publisher: Georg Thieme Verlag

URL: http://dx.doi.org/10.1055/s-0032-1311607

DOI: 10.1055/s-0032-1311607

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