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Lookup NU author(s): Dr Andrew Ford,
Dr Gordon Duncan,
Dr Michael FirbankORCiD,
Dr Alison Yarnall,
Dr Tien Khoo,
Professor David Burn,
Professor John O'Brien
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Background: Rapid eye movement sleep behavior disorder has poor prognostic implications for Parkinson's disease. The authors recruited 124 patients with early Parkinson's disease to compare clinical and neuroimaging findings based on the presence of this sleep disorder. Methods: The presence of rapid eye movement sleep behavior disorder was assessed with the Mayo Sleep Questionnaire. Magnetic resonance imaging sequences were obtained for voxel-based morphometry and diffusion tensor imaging. Results: Patients with sleep disorder had more advanced disease, but groups had similar clinical characteristics and cognitive performance. Those with sleep disorder had areas of reduced cortical grey matter volume and white matter changes compared with those who did not have sleep disorder. However, differences were slight and were not significant when the analyses were adjusted for multiple comparisons. Conclusions: Rapid eye movement sleep behavior disorder was associated with subtle changes in white matter integrity and grey matter volume in patients with early Parkinson's disease.
Author(s): Ford AH, Duncan GW, Firbank MJ, Yarnall AJ, Khoo TK, Burn DJ, O'Brien JT
Publication type: Article
Publication status: Published
Journal: Movement Disorders
Print publication date: 01/06/2013
Online publication date: 28/02/2013
Acceptance date: 19/12/2012
Date deposited: 18/03/2013
ISSN (print): 0885-3185
ISSN (electronic): 1531-8257
Publisher: John Wiley & Sons, Inc.
PubMed id: 23450684
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