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Short latency afferent inhibition: A biomarker for mild cognitive impairment in Parkinson's disease?

Lookup NU author(s): Professor Alison Yarnall, Professor Lynn RochesterORCiD, Professor Mark BakerORCiD, Dr Tien Khoo, Dr Gordon Duncan, Dr Brook Galna, Professor David Burn


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BACKGROUND: Mild cognitive impairment in Parkinson's disease (PD) is common and predicts those at risk of dementia. Cholinergic dysfunction may contribute to its pathophysiology and can be assessed using short latency afferent inhibition. METHODS: Twenty-two patients with PD (11 cognitively normal; 11 with mild cognitive impairment) and 22 controls participated. Short latency afferent inhibition was measured by conditioning motor evoked potentials, which were elicited by transcranial magnetic stimulation of the motor cortex with electricalstimuli delivered to the contralateral median nerve at varying interstimulus intervals. RESULTS: There was no significant difference between cognitively normal PD and controls for short latency afferent inhibition (62.8±30.3% vs. 55.7±21.7%; P=0.447). The PD-mild cognitive impairment group had significantly less inhibition (88.4±25.8%) than both cognitively normal PD (P=0.021) andcontrols (P=0.01). CONCLUSIONS: Cholinergic dysfunction occurs early in those with PD -mild cognitive impairment. Short latency afferent inhibition may be a useful biomarker of increased risk of dementia in PD patients.

Publication metadata

Author(s): Yarnall AJ, Rochester L, Baker MR, David R, Khoo TK, Duncan GW, Galna B, Burn DJ

Publication type: Article

Publication status: Published

Journal: Movement Disorders

Year: 2013

Volume: 28

Issue: 9

Pages: 1285-1288

Print publication date: 01/08/2013

Online publication date: 28/02/2013

Acceptance date: 09/12/2012

Date deposited: 18/03/2013

ISSN (print): 0885-3185

ISSN (electronic): 1531-8257

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/mds.25360

PubMed id: 23450646


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