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Compensatory weight gain due to dopaminergic hypofunction: new evidence and own incidental observations

Lookup NU author(s): Dr Iwo Bohr


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There is increasing evidence for a role of dopamine in the development of obesity. More specifically, dopaminergic hypofunction might lead to (over)compensatory food intake. Overeating and resulting weight gain may be induced by genetic predisposition for lower dopaminergic activity, but might also be a behavioral mechanism of compensating for decreased dopamine signaling after dopaminergic overstimulation, for example after smoking cessation or overconsumption of high palatable food. This hypothesis is in line with our incidental finding of increased weight gain after discontinuation of pharmaceutical dopaminergic overstimulation in rats. These findings support the crucial role of dopaminergic signaling for eating behaviors and offer an explanation for weight-gain after cessation of activities associated with high dopaminergic signaling. They further support the possibility that dopaminergic medication could be used to moderate food intake.

Publication metadata

Author(s): Reinholz J, Skopp O, Breitenstein C, Bohr I, Winterhoff H, Knecht S

Publication type: Article

Publication status: Published

Journal: Nutrition and Metabolism

Year: 2008

Volume: 5

ISSN (electronic): 1743-7075

Publisher: BioMed Central Ltd.


DOI: 10.1186/1743-7075-5-35

Notes: Article no. 35 is 4 pp.


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