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Lookup NU author(s): Dr Iwo Bohr, Dr Eva Lowther, Professor Andrew BlamireORCiD, Professor John O'Brien, Professor Alan ThomasORCiD, Dr Jonathan Richardson
Functional magnetic resonance imaging recordings in the resting-state (RS) from the human brain are characterized by spontaneous low-frequency fluctuations in the blood oxygenation level dependent signal that reveal functional connectivity (FC) via their spatial synchronicity. This RS study applied network analysis to compare FC between late-life depression (LLD) patients and control subjects. Raw cross-correlation matrices (CM) for LLD were characterized by higher FC. We analyzed the small-world (SW) and modular organization of these networks consisting of 110 nodes each as well as the connectivity patterns of individual nodes of the basal ganglia. Topological network measures showed no significant differences between groups. The composition of top hubs was similar between LLD and control subjects, however in the LLD group posterior medial-parietal regions were more highly connected compared to controls. In LLD, a number of brain regions showed connections with more distant neighbors leading to an increase of the average Euclidean distance between connected regions compared to controls. In addition, right caudate nucleus connectivity was more diffuse in LLD. In summary, LLD was associated with overall increased FC strength and changes in the average distance between connected nodes, but did not lead to global changes in SW or modular organization.
Author(s): Bohr IJ, Kenny E, Blamire A, O'Brien JT, Thomas AJ, Richardson J, Kaiser M
Publication type: Article
Publication status: Published
Journal: Frontiers in Psychiatry
Year: 2013
Volume: 3
Print publication date: 09/01/2013
Date deposited: 24/04/2013
ISSN (electronic): 1664-0640
Publisher: Frontiers Research Foundation
URL: http://dx.doi.org/10.3389/fpsyt.2012.00116
DOI: 10.3389/fpsyt.2012.00116
Notes: Article no. 116 is 14 pp.
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