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Resting-state functional connectivity in late-life depression: higher global connectivity and more long distance connections

Lookup NU author(s): Dr Iwo Bohr, Dr Eva Lowther, Professor Andrew BlamireORCiD, Professor John O'Brien, Professor Alan ThomasORCiD, Dr Jonathan Richardson



Functional magnetic resonance imaging recordings in the resting-state (RS) from the human brain are characterized by spontaneous low-frequency fluctuations in the blood oxygenation level dependent signal that reveal functional connectivity (FC) via their spatial synchronicity. This RS study applied network analysis to compare FC between late-life depression (LLD) patients and control subjects. Raw cross-correlation matrices (CM) for LLD were characterized by higher FC. We analyzed the small-world (SW) and modular organization of these networks consisting of 110 nodes each as well as the connectivity patterns of individual nodes of the basal ganglia. Topological network measures showed no significant differences between groups. The composition of top hubs was similar between LLD and control subjects, however in the LLD group posterior medial-parietal regions were more highly connected compared to controls. In LLD, a number of brain regions showed connections with more distant neighbors leading to an increase of the average Euclidean distance between connected regions compared to controls. In addition, right caudate nucleus connectivity was more diffuse in LLD. In summary, LLD was associated with overall increased FC strength and changes in the average distance between connected nodes, but did not lead to global changes in SW or modular organization.

Publication metadata

Author(s): Bohr IJ, Kenny E, Blamire A, O'Brien JT, Thomas AJ, Richardson J, Kaiser M

Publication type: Article

Publication status: Published

Journal: Frontiers in Psychiatry

Year: 2013

Volume: 3

Print publication date: 09/01/2013

Date deposited: 24/04/2013

ISSN (electronic): 1664-0640

Publisher: Frontiers Research Foundation


DOI: 10.3389/fpsyt.2012.00116

Notes: Article no. 116 is 14 pp.


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