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Common Variation Neighbouring Micro-RNA 22 Is Associated with Increased Left Ventricular Mass

Lookup NU author(s): Dr Thahira Rahman, Valentina Mamasoula, Dr Peter Avery, Professor Bernard Keavney

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Abstract

Aims: Previous genome-wide linkage analysis has suggested that chromosomal region 17p13.3 may harbour genes influencing left ventricular mass (LVM) in man. To date, the genetic factors accounting for LVM variability remain largely unknown but a non-coding RNA gene within this region, micro-RNA 22 (miR-22), has been implicated in cardiac hypertrophy and heart failure in animal models. We thus investigated the relationship between common genetic polymorphisms surrounding miR-22 and left ventricular mass in a family-based association study. Methods and Results: We studied a cohort of 255 families comprising 1,425 individuals ascertained via a hypertensive proband. Ten single nucleotide polymorphisms which together tagged common genetic variation surrounding the miR-22 gene were genotyped. There was evidence of association between the rs7223247 polymorphism, which lies within the 3'UTR of a gene of unknown function, TLCD2, immediately downstream from miR-22, and left ventricular mass determined by Sokolow-Lyon voltage (Bonferroni corrected p-value = 0.038). The T allele at rs7223247 was associated with an 0.272 standard deviation higher Sokolow-Lyon voltage. Genotype was responsible for similar to 1% of the population variability in LVM. Conclusions: Genotype at the rs7223247 polymorphism affects left ventricular mass determined by Sokolow-Lyon voltage. The neighbouring genes miR-22 and TLCD2 are strong candidates to account for this observation.

Publication metadata

Author(s): Harper AR, Mayosi BM, Rodriguez A, Rahman T, Hall D, Mamasoula C, Avery PJ, Keavney BD

Publication type: Article

Publication status: Published

Journal: PLoS One

Year: 2013

Volume: 8

Issue: 1

Print publication date: 01/01/2013

Date deposited: 11/07/2013

ISSN (print): 1932-6203

ISSN (electronic): 1544-9173

Publisher: Public Library of Science

URL: http://dx.doi.org/10.1371/journal.pone.0055061

DOI: 10.1371/journal.pone.0055061

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