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Lookup NU author(s): Dr Martyna PastokORCiD
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USP4, 11 and 15 are three closely related paralogues of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. The DUSP domain and the UBL domain in these proteins are juxtaposed which may provide a functional unit conferring specificity. We determined the structures of the USP15 DUSP-UBL double domain unit in monomeric and dimeric states. We then conducted comparative analysis of the structural and physical properties of all three DUSP-UBL units. We identified structural features that dictate different dispositions between constituent domains, which in turn may influence respective binding properties
Author(s): Elliott PR, Liu H, Pastok MW, Grossmann GJ, Rigden DJ, Clague MJ, Urbé S, Barsukov IL
Publication type: Article
Publication status: Published
Journal: FEBS Letters
Year: 2011
Volume: 585
Issue: 21
Pages: 3385–3390
Print publication date: 10/10/2011
ISSN (print): 0014-5793
ISSN (electronic): 1873-3468
Publisher: Elsevier BV
URL: http://dx.doi.org/10.1016/j.febslet.2011.09.040
DOI: 10.1016/j.febslet.2011.09.040
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