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Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old

Lookup NU author(s): Dr Joanna Collerton, Dr Angela Pyle, Professor Gavin Hudson, Mohammad Yadegarfar, Dr Karen Davies, Emerita Professor Carol Jagger, Professor Thomas von Zglinicki, Emeritus Professor Thomas Kirkwood, Professor Patrick Chinnery



Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an "unhealthy aging" phenotype) or mortality in 700, more than 85-year-old, participants of the Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently no compelling link between inherited mtDNA variants and aging.

Publication metadata

Author(s): Collerton J, Ashok D, Martin-Ruiz C, Pyle A, Hudson G, Yadegarfar M, Davies K, Jagger C, von Zglinicki T, Kirkwood T, Chinnery P

Publication type: Article

Publication status: Published

Journal: Neurobiology of Aging

Year: 2013

Volume: 34

Issue: 12

Pages: 2889.e1-2889.e4

Print publication date: 30/04/2013

Date deposited: 27/11/2013

ISSN (print): 0197-4580

ISSN (electronic): 1558-1497

Publisher: Elsevier Inc.


DOI: 10.1016/j.neurobiolaging.2013.04.001


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Funder referenceFunder name
Medical Research Council
Newcastle University
NIHR Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust
084980/Z/08/ZWellcome Trust
096919Z/11/ZWellcome Trust
G0601333Biotechnology and Biological Sciences Research Council
G0500997Biotechnology and Biological Sciences Research Council